Journal article
Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease
SG Royce, W Dang, K Ververis, N de Sampayo, A El Osta, MLK Tang, TC Karagiannis
Epigenetics | TAYLOR & FRANCIS INC | Published : 2011
Abstract
Airway remodeling and airway hyperresponsiveness are major aspects of asthma pathology that are not targetedoptimally by existing anti-inflammatory drugs, Histone deacetylase inhibitors have a wide range of effects that maypotentially abrogate aspects of remodeling, One such histone deacetylase inhibitor is valproic acid (2-propylvaleric acid).Valproic acid is used clinically as an anti-epileptic drug and is a potent inhibitor of class I histone deacetylases but alsoinhibits class II histone deacetylases, We used valproic acid as a molecular model of histone deacetylase inhibition invivo in chronic allergic airways disease mice with airway remodeling and airway hyperresponsiveness, Wild-type..
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Funding Acknowledgements
The authors wish to thank Ms. Jenny Tran and Ms. Yuan Gao for their laboratory assistance. Studies were funded by an Australian National Health and Medical Research Council (NHMRC) project grants (546428, 566559, 566559) and a Murdoch Children's Research Institute Infection, Environment and Immunity Grant. Further, the authors acknowledge grant and fellowship support from the Australian Institute of Nuclear Science and Engineering (AINSE) and the CRC for Biomedical Imaging Development (CRC-BID).